Cell Sorting in an Active Nematic Vertex Model
Physical Review Letters American Physical Society (APS) 133:24 (2024) 248401
Abstract:
<jats:p>We study a mixture of extensile and contractile cells using a vertex model extended to include active nematic stresses. The two cell populations phase separate over time. While phase separation strengthens monotonically with an increasing magnitude of contractile activity, the dependence on extensile activity is nonmonotonic, so that sufficiently high values reduce the extent of sorting. We interpret this by showing that extensile activity renders the system motile, enabling cells to undergo neighbor exchanges. Contractile cells that come into contact as a result are then more likely to stay connected due to an effective attraction arising from contractile activity.</jats:p> <jats:sec> <jats:title/> <jats:supplementary-material> <jats:permissions> <jats:copyright-statement>Published by the American Physical Society</jats:copyright-statement> <jats:copyright-year>2024</jats:copyright-year> </jats:permissions> </jats:supplementary-material> </jats:sec>Self organisation of invasive breast cancer driven by the interplay of active and passive nematic dynamics
(2024)
Topologically frustrated structures in inkjet printed chiral nematic liquid crystal droplets – experiments and simulations
Soft Matter Royal Society of Chemistry (2024)
Abstract:
Director field alignment in inkjet printed droplets of chiral nematic liquid crystalline materials is investigated using both experiments and numerical simulations. Experimental investigations are performed by depositing droplets of varying sizes and pitches on homeotropic alignment layers. The competition between the bulk behaviour of the chiral nematic liquid crystal and the boundary conditions imposed by the droplet surface leads to the formation of a range of possible internal director configurations. Numerical investigations are performed using a free energy minimisation approach, and the resultant simulated polarising optical microscope images are found to agree well with experimental observations.Phase ordering in binary mixtures of active nematic fluids.
Physical review. E American Physical Society (APS) 110:2-1 (2024) 24607
Abstract:
We use a continuum, two-fluid approach to study a mixture of two active nematic fluids. Even in the absence of thermodynamically driven ordering, for mixtures of different activities we observe turbulent microphase separation, where domains form and disintegrate chaotically in an active turbulent background. This is a weak effect if there is no elastic nematic alignment between the two fluid components, but is greatly enhanced in the presence of an elastic alignment or substrate friction. We interpret the results in terms of relative flows between the two species which result from active anchoring at concentration gradients. Our results may have relevance in interpreting epithelial cell sorting and the dynamics of multispecies bacterial colonies.An introduction to phase ordering in scalar active matter
European Physical Journal - Special Topics EDP Sciences 233:17 (2024) 2701-2710