Atmospheric processes

El Niño Southern Oscillation (ENSO) events yield precipitation deficits and ensuing droughts, often damaging regional forests, in many parts of the world. The relative roles of ENSO, other natural climate changes, and anthropogenic factors on the forest clearing of Easter Island over the last millennium are still debated. Here, we analyze Easter Island precipitation changes using in situ, satellite-derived and reanalysis products spanning the last 4–7 decades, and 46 monthly 156-year-long (1850–2014) simulations derived from 25 CMIP5 and 21 CMIP6 (Coupled Model Intercomparison Project phases 5 and 6) General Circulation Models. Our analysis shows that La Niña events, the cold phases of ENSO, cause precipitation deficits of −0.2 to −0.3 standard deviation (relative to long-term mean) in all analyzed data types. ENSO-like events are further examined over the last millennium (850–1981). A new multiproxy reconstruction of the NINO3.4 index based on proxy records from the Past Global Changes 2k database and Random Forest method is produced. Our reconstruction reveals unusual high recurrences of La Niña-like situations during the fifteenth to seventeenth centuries, which likely induced significant precipitation deficits on the island. These situations are compared to published vegetation reconstructions based on pollen analyses derived from sedimentary cores collected in three island sites. We conclude the environmental consequences of cumulative precipitation deficits over long-lasting La Niña-like situations reconstructed here over the fifteenth to seventeenth centuries were likely favoring drought and forest flammability. La Niña events should be better accounted for among the causes of forest clearing on Easter Island.

Atlantic multidecadal variability is a coherent mode of natural climate variability occurring in the North Atlantic Ocean, with strong impacts on human societies and ecosystems worldwide. However, its periodicity and drivers are widely debated due to the short temporal extent of instrumental observations and competing effects of both internal and external climate factors acting on North Atlantic surface temperature variability. Here, we use a paleoclimate database and an advanced statistical framework to generate, evaluate, and compare 312 reconstructions of the Atlantic multidecadal variability over the past millennium, based on different indices and regression methods. From this process, the best reconstruction is obtained with the random forest method, and its robustness is checked using climate model outputs and independent oceanic paleoclimate data. This reconstruction shows that memory in variations of Atlantic multidecadal variability have strongly increased recently—a potential early warning signal for the approach of a North Atlantic tipping point.

The identification of essential genes, i.e. those that impair cell survival when deleted, requires large growth assays of knock-out strains. The complexity and cost of such experiments has triggered a growing interest in computational methods for prediction of gene essentiality. In the case of metabolic genes, Flux Balance Analysis (FBA) is widely employed to predict essentiality under the assumption that cells maximize their growth rate. However, this approach assumes that knock-out strains optimize the same objectives as the wild-type, which excludes cases in which deletions cause large physiological changes to meet other objectives for survival. Here, we resolve this limitation with a novel machine learning approach that predicts essentiality directly from wild-type flux distributions. We first project the wild-type FBA solution onto a mass flow graph, a digraph with reactions as nodes and edge weights proportional to the mass transfer between reactions, and then train binary classifiers on the connectivity of graph nodes. We demonstrate the efficacy of this approach using the most complete metabolic model of Escherichia coli, achieving near state-of-the art prediction accuracy for essential genes. Our approach suggests that wild-type FBA solutions contain enough information to predict essentiality, without the need to assume optimality of deletion strains.